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HIV is an infectious disease that is caused by human immunodeficiency virus.
The replication and progression of this infection leading to significant decline in CD4 cell count and AIDS disease require a very high level of chronic pro-inflammatory condition.
The replication of HIV begins with the high affinity binding of the gp 120 protein binding of CD4 cell surface to the host cell. This helps a conformational change that facilitates binding to the co – receptors of CCR5 and CXCR4. Both receptors belong to the class of G-protein coupled cellular receptors. Following fusion and entry of genomic RNA of HIV into host CD4 cell, the RNA is uncoated and is internalized into host cell. The reverse transcription of the infecting virus catalyzes the genomic RNA into double stranded DNA. This DNA is later imported to the nucleus of the host cell. Thereafter this can produce fresh virions and replicate.
Cellular activation plays an important role in the life cycle of HIV and is critical to the pathogenesis of HIV disease. Activation is by way of Cytokines.
If HIV enters a resting CD4 cell, only a limited degree of reverse transcription of the HIV, genome occurs. This period of pre-integration latency may last few hours to days. If no activation signal is delivered to the cell, the provirus DNA loses its capacity to initiate a productive infection as reverse transcription does not go into completion. The pre-integration complex is imported into host cell-nucleus for replication again under activated conditions.
Indus is developing a drug candidate that inhibits activation of CD4 cells by Biological Response Modification leading to inhibition of HIV Replication and preservation of the CD4 cell pool.
The replication and progression of this infection leading to significant decline in CD4 cell count and AIDS disease require a very high level of chronic pro-inflammatory condition.
The replication of HIV begins with the high affinity binding of the gp 120 protein binding of CD4 cell surface to the host cell. This helps a conformational change that facilitates binding to the co – receptors of CCR5 and CXCR4. Both receptors belong to the class of G-protein coupled cellular receptors. Following fusion and entry of genomic RNA of HIV into host CD4 cell, the RNA is uncoated and is internalized into host cell. The reverse transcription of the infecting virus catalyzes the genomic RNA into double stranded DNA. This DNA is later imported to the nucleus of the host cell. Thereafter this can produce fresh virions and replicate.
Cellular activation plays an important role in the life cycle of HIV and is critical to the pathogenesis of HIV disease. Activation is by way of Cytokines.
If HIV enters a resting CD4 cell, only a limited degree of reverse transcription of the HIV, genome occurs. This period of pre-integration latency may last few hours to days. If no activation signal is delivered to the cell, the provirus DNA loses its capacity to initiate a productive infection as reverse transcription does not go into completion. The pre-integration complex is imported into host cell-nucleus for replication again under activated conditions.
Indus is developing a drug candidate that inhibits activation of CD4 cells by Biological Response Modification leading to inhibition of HIV Replication and preservation of the CD4 cell pool.
