Research & Development
Our proprietory platform technology forms the basis for our innovative product development. This technology enables us to evaluate novel compositions from food chain raw materials, allowing us to create intellectual property for long term value creation.
212
Patents
granted
granted
with
92
Patents
applied
applied
and
34
Patents
total
total
We collaborate with reputed academic institutions and research organizations to ensure robust innovative products.
72
papers in
peer reviewed journals
peer reviewed journals
with
59
conference presentations
Our research & development excel in
Our research & development excel in
fenugreek seeds
cinnamon bark
gotu kola leaves
Fenugreek (Scientific Name: Trigonella foenum-gracum) seeds have stood the test of time as a medicinal plant. Fenugreek is an integral part of many traditional healing systems. The multiple medicinal benefits of Fenugreek seeds have led to a focus on it as a nutritional supplement.
We, at Indus Biotech, have pioneered research on Fenugreek seeds. Our R&D has led to the discovery of many bioactive molecules in Fenugreek seeds. Our science has harnessed the potential of these molecules for promising healthcare applications.
Cinnamon (Scientific Name: Cinnamomum zeylanicum) bark is a traditional treatment for inflammation, pain, fever and arthritis. Cinnamon bark also boosts immunity.
Our research on Cinnamon bark has led to the identification of specific polyphenols effective against chronic immune and infectious conditions including allergic rhinitis.
Gotu Kola (Scientific Name: Centella asiatica) leaves are part of Asian and African healing systems. The medicinal properties of Gotu Kola are derived from constituents called Triterpenes.
With our platform technology we have identified and characterized our patented composition of Triterpene molecules.
We have developed patented standardized products from fenugreek seeds containing:
Hydroxyisolueicne
(a major amino acid)
(a major amino acid)
Trigonelline
(a major alkaloid)
(a major alkaloid)
Oligosaccharide/
Galactomannan/
Soluble Fibers
Galactomannan/
Soluble Fibers
Glycosides and
Furostenol Saponins
Furostenol Saponins
Type A Proanthocyanidin Polyphenol
Asiaticoside
Madecassoside
List of Patents and Publications
List of Patents and Publications
Raw Material
Products
Sr. No.
Year
Title
Journal, Volume, Page No.
View
1
Testofen (Fenugreek extract) increases strength and muscle mass compared to placebo in response to calisthenics. A randomized control trial
2020
Translational Sports Medicine*, 2020: 1-7
2
Effects of low molecular weight galactomannans based standardized fenugreek seed extract in subjects with high fat mass: A randomized, double-blind, placebo-controlled clinical study
2019
Journal of Applied Pharmaceutical Science*, 10 (1): 62-69
3
A systematic literature review of fenugreek seed toxicity by using ToxRTool: Evidence from preclinical and clinical studies
2019
HELIYON*, 5 (4): e01536
4
Efficacy and safety of standardized cinnamon bark extract for the prevention of chemotherapy-induced weight loss and alopecia in patients with breast cancer: A randomized, double-blind, placebo-controlled study
2019
Asian Journal of Pharmaceutical and Clinical Research*, 12 (10): 163-168
5
A randomized, double-blind placebo-controlled study of intranasal standardized cinnamon bark extract for seasonal allergic rhinitis
2019
Complementary Therapies in Medicine*, 47: 102198
6
Efficacy and Safety of Herbal Formulation Rich in Standardized Fenugreek Seed Extract as Add-On Supplementation in Patients with Type 2 Diabetes Mellitus on Sulphonylurea Therapy: A 12-Week, Randomized, Double-Blind, Placebo-Controlled, Multi-Center Study
2018
Pharmacognosy Magazine (Accepted.)
7
Anti-obesity action of INDUS810, a natural compound from Trigonella foenum-graecum: AMPK-dependent lipolysis effect in adipocytes
2018
Obesity Research and Clinical Practice*, 12 (6): 562-569
8
Add-on therapy of herbal formulation rich in standardized fenugreek seed extract in type 2 diabetes mellitus patients with insulin therapy: An efficacy and safety study
2018
Asian Pacific Journal of Tropical Biomedicine*, 8 (9): 446-455
9
Low molecular weight galactomannans based standardized fenugreek seed extract ameliorates High-Fat Diet-induced obesity in mice via modulation of FASn, IL-6, Leptin, and TRIP-Br-2
2018
RCS Advances*, 8: 32401
10
Preclinical safety assessment of furostanol glycoside based standardized fenugreek seed extract in laboratory rats
2017
Journal of Dietary Supplements 14(5): 521-541.
11
Prenatal developmental toxicity study of glycosides based standardized fenugreek seed extract in rats
2017
Pharmacognosy Magazine 13(49): 135-141.
12
Prenatal developmental toxicity evaluation of IDM01, a botanical composition of 4-hydroxyisoleucine- and trigonelline-based standardized fenugreek seed extract, during organogenesis period of pregnancy in rats
2017
Journal of Applied Pharmaceutical Science 7(10): 62-69.
13
Preclinical toxicological evaluation of IDM01: The botanical composition of 4-Hydroxyisoleucine- and trigonelline-based standardized fenugreek seed extract
2017
Pharmacognosy Research 9(2): 138-150.
14
A cinnamon-derived procyanidin type A compound inhibits hepatitis C virus cell entry
2017
Hepatology International 11(5): 440-445
15
Ameliorative effects of type-A procyanidine polyphenols from cinnamon bark in compound 48/80-induced mast cell degranulation
2017
Anatomy and Cell Biology 50: 275-284.
16
Glycosides Based Standardized Fenugreek Seed Extract Ameliorates Bleomycin-Induced Liver Fibrosis in Rats via Modulation of Endogenous Enzymes
2017
Journal of Pharmacy and Bioallied Sciences 9(3): 185-194.
17
Efficacy of a Proprietary Trigonella foenum-graecum L. De-Husked Seed Extract in Reducing Menopausal Symptoms in Otherwise Healthy Women: A Double-Blind, Randomized, Placebo-Controlled Study
2017
Phytother Res 31(9): 1316-1322
18
Effects of IBPR, a proprietary blend rich in glycoside based standardized fenugreek seed extract on inflammatory markers during acute eccentric resistance exercise in young subjects
2017
Asian Journal of Pharmaceutical and Clinical Research 10(10): 99-104.
19
A Cinnamon-Derived Procyanidin Compound Displays Anti-HIV-1 Activity by Blocking Heparan Sulfate- and Co-Receptor- Binding Sites on gp120 and Reverses T Cell Exhaustion via Impeding Tim-3 and PD-1 Upregulation
2016
Plos One 11(10): e0165386.
20
Prenatal developmental toxicity evaluation of low molecular weight galactomannans based standardized fenugreek seed extract during organogenesis period of pregnancy in rats
2016
International Journal of Pharmacy and Pharmaceutical Sciences 8(5): 248-253.
21
Preclinical safety assessment of glycosides based standardized fenugreek seeds extract: Acute, subchronic toxicity and mutagenicity studies
2016
Journal of Applied Pharmaceutical Science 6(9): 179-188.
22
Preclinical safety evaluation of low molecular weight galactomannans based standardized fenugreek seeds extract
2016
EXCLI Journal 15: 446-459.
23
Gastroprotective effect of Fenugreek 4-hydroxyisoleucine and trigonelline enriched fraction (TF4H (28%)) Sugaheal® against indomethacin induced ulcer in male wistar rats
2016
Journal of Pharmacy Research 10(6): 351-364.
24
Development and validation of HPLC method for Vicenin-1 isolated from fenugreek seeds in rat plasma-Application to pharmacokinetic, tissue distribution and excretion studies
2016
Pharmaceutical Biology 14: 1-9.
25
Acute and repeated doses (28 days) oral toxicity study of Vicenin-1, a flavonoid glycoside isolated from fenugreek seeds in laboratory mice
2016
Regulatory Toxicology and Pharmacology 81: 522-531.
26
Testofen, a specialised Trigonella foenum-graecum seed extract reduces age-related symptoms of androgen decrease, increases testosterone levels and improves sexual function in healthy aging males in a double-blind randomised clinical study
2016
Aging Male Jan(2): 1-9.
27
Beneficial effects of fenugreek glycoside supplementation in male subjects during resistance training: A randomized controlled pilot study
2016
Journal of Sport and Health Science 5(2): 176-182.
28
Prenatal developmental toxicity evaluation of furostanol glycoside based standardized fenugreek seed extract during organogenesis period of pregnancy in rats
2016
International Journal of Pharmacy and Pharmaceutical Sciences*, 8 (12): 124-129
29
Anti-allergic Effect of Intranasal Administration of Type-A Procyanidine Polyphenols Based Standardized Extract of Cinnamon Bark in Ovalbumin sensitized BALB/c Mice [Unwas award for best paper]
2015
Phytotherapy Research 29: 23?433.
30
Prophylactic effects of asiaticoside based standardized extract of Centella asiatica (L.) Urban leaves in experimental migraine: Involvement of 5HT1A/1B receptors
2015
Chinese Journal of Natural Medicines 13(4): 274-282.
31
Preclinical safety assessment of standardized extract of Centella asiatica (L.) Urban leaves
2015
Toxicology International 22: 10-20.
32
Effects of 4-hydroxyisoleucine from Fenugreek Seeds on Depression-like Behavior in Socially Isolated Olfactory Bulbectomized Rats
2015
Pharmacognosy Magazine 11(44): S388-S396.
33
Acute and repeated doses (28 days) oral toxicity study of glycosides based standardized fenugreek seed extract in laboratory mice
2015
Regulatory Toxicology and Pharmacology 72: 323-334.
34
Effect of glycosides based standardized fenugreek seed extract in bleomycin-induced pulmonary fibrosis in rats: decisive role of Bax, Nrf2, NF-kappaB, Muc5ac, TNF-alpha and IL-1beta
2015
Chemico-Biological Interactions 237: 151-165.
35
Prophylactic efficacy and possible mechanisms of oligosaccharides based standardized fenugreek seed extract on high-fat diet-induced insulin resistance in C57BL/6 mice
2015
Journal of Applied Pharmaceutical Science 5(3): 35-45.
36
Pharmacokinetics, tissue distribution and excretion study of furostanol glycosides based standardized fenugreek seed extract in rats through solid-liquid extraction method
2015
Renal Failure 37(7): 1208-1218.
37
Derivation of Cinnamon Blocks Leukocyte Attachment by Interacting with Sialosides
2015
PLoS One 10(6): e0130389.
38
Influence of a Specialized Trigonella foenum-graecum Seed Extract (Libifem), on Testosterone, Estradiol and Sexual Function in Healthy Menstruating Women, a Randomised Placebo Controlled Study
2015
Phytotherapy Research 29(8): 1123-1130.
39
Anti-allergic Effect of Intranasal Administration of Type-A Procyanidine Polyphenols Based Standardized Extract of Cinnamon Bark in Ovalbumin sensitized BALB/c Mice [Unwas award for best paper-IPSCON2015-Rajkot]
2015
Phytotherapy Research*, 29: 23–433
40
Prophylactic effects of asiaticoside based standardized extract of Centella asiatica (L.) Urban leaves in experimental migraine: Involvement of 5HT1A/1B receptors
2015
Chinese Journal of Natural Medicines*, 13 (4): 274-282
41
Modulatory activity of a polyphenolic fractions of Cinnamomum zeylanicum L. bark on multiple arms of immunity in normal and immunocompromised mice
2014
Journal of Applied Pharmaceutical Science 4(7): 114-122.
42
Trigonelline [99%] Protects against Copper-Ascorbate Induced Oxidative Damage to Aortic Mitochondria In vitro: Involvement of Antioxidant Mechanism(s)
2014
International Journal of Pharmaceutical Sciences, Reviews and Research (IJPSRR) 29(2): 312-323.
43
Antioxidant mechanism (s) of protective effects of Fenugreek 4-hydroxyisoleucine and trigonelline enriched fraction (TF4H (28%)) Sugaheal against copper-ascorbate induced injury to goat cardiac mitochondria in vitro
2014
Journal of Pharmacy Research 8(6): 798-811.
44
Trigonelline [99%] protects against copper-ascorbate induced oxidative damage to mitochondria: an in vitro study
2014
International Journal of Pharmaceutical Sciences Review and Research, 29(2): 312-323.
45
Effects of glycosides based fenugreek seed extract on serum testosterone levels of healthy sedentary male subjects: A exploratory double blind, placebo controlled, crossover study
2014
Asian Journal of Pharmaceutical and Clinical Research 7(2): 177-181.
46
Isolation of (2S,3R,4S)-4-Hydroxyisoleucine from Trigonella foenum graecum Seeds
2014
Asian Journal of Chemistry 26(10): 3082-3084.
47
Efficacy and safety of standardized extract of Trigonella foenum-graecum L seeds as an adjuvant to L-dopa in the management of patients with Parkinson's disease
2014
Phytotherapy Research 28: 172-178.
48
Parkinson's Disease Progression Slowed by Adjunctive Fenugreek Extract
2014
HerbalGram Fall(103): 33.
49
Efficacy and safety of intranasal cinnamon bark extract in seasonal allergic rhinitis patients: A double-blind placebo-controlled pilot study
2014
Journal of Herbal Medicine 4: 37-47.
50
Efficacy and safety of standardized extract of Trigonella foenum-graecum L seeds as an adjuvant to L-dopa in the management of patients with Parkinson’s disease
2014
Phytotherapy Research*, 28: 172-178
51
Parkinson’s Disease Progression Slowed by Adjunctive Fenugreek Extract
2014
HerbalGram*, Fall (103): 33
52
Efficacy and safety of the topical use of intranasal cinnamon bark extract in seasonal allergic rhinitis patients: A double-blind placebo-controlled pilot study
2014
Journal of Herbal Medicine*, 4: 37-47
53
Neurobehavioral assessment of hydroalcoholic extract of Trigonella foenum-graecum seeds in rodent models of Parkinson's disease
2013
Pharm Biol 51(5): 550-557.
54
Effect of low molecular weight galactomannans from fenugreek seeds on animal models of diabetes mellitus
2013
Biomedicine & Aging Pathology 3: 145-151.
55
Anti-asthmatic effects of type-A procyanidine polyphenols from cinnamon bark in ovalbumin-induced airway hyperresponsiveness in laboratory animals
2013
Biomedicine and Aging Pathology 3(1): 23-30.
56
Ameliorative effects of a polyphenolic fraction of Cinnamomum zeylanicum L. bark in animal models of inflammation and arthritis
2013
Scientia Pharmaceutica 81(2): 567?589.
57
Therapeutic effects of standardized fenugreek seed extract on experimental urolithiasis in rats
2013
Journal of Applied Pharmaceutical Science*, 3 (9): 29-35
58
Anti-inflammatory and anti-arthritic activity of type-A procyanidine polyphenols from bark of Cinnamomum zeylanicum in rats
2013
Food Science and Human Wellness*, 2: 59-67
59
Renoprotective effects of reconstructed composition of Trigonella foenum-graecum L. seeds in animal model of diabetic nephropathy with and without renal ischemia reperfusion in rats
2012
International Journal of Pharmacology 8(5): 321-332.
60
Antidepressant-like effect of 4-hydroxyisoleucine from Trigonella foenum graecum L.?seeds in mice
2012
Biomedicine & Aging Pathology 2(3): 121-125.
61
Antidepressant effects of standardized extract of Centella asiatica L in olfactory bulbectomy model
2012
Biomedicine & Aging Pathology 2(2): 48-53.
62
Antidiabetic activity of Trigonella foenum-graecum L. seeds extract (IND01) in neonatal streptozotocin-induced (n-STZ) rats
2012
Diabetologia Croatica 41(1): 29-40.
63
Ameliorative effects of standardized extract from Trigonella foenum-graecum L. seeds, on painful peripheral neuropathy in rats
2012
Asian Pacific Journal of Tropical Medicine 5(5): 385-390.
64
Antidepressant-like effect of 4-hydroxyisoleucine from Trigonella foenum graecum L. seeds in mice
2012
Biomedicine & Aging Pathology*, 2 (3): 121-125
65
Physiological aspects of male libido enhanced by standardized Trigonella foenum-graecum extract and mineral formulation
2011
Phytother Res 25(9): 1294-300.
66
Effects of combined creatine plus fenugreek extract vs. Creatine plus carbohydrate supplementation on resistance training adaptations
2011
Journal of Sports Science and Medicine 10: 254-260.
67
Effect of Furostanol Glycosides from Trigonella foenum-graecum on the reproductive system of male albino rats
2010
Phytotherapy Research 24: 1482?1488.
68
Ayurveda-modern medicine interface: A critical appraisal of studies of Ayurvedic medicines to treat osteoarthritis and rheumatoid arthritis
2010
J Ayurveda Integr Med 1(3): 190-8.
69
The effects of a commercially available botanical supplement on strength, body composition, power output, and hormonal profiles in resistance-trained males
2010
J Int Soc Sports Nutr 7: 34.
70
Effects of a Purported Aromatase and 5 a-Reductase Inhibitor on Hormone Profiles in College-Age Men
2010
International journal of sport nutrition 20(6): 457.
71
Effect of trigonelline on fertility in female rats
2009
International Journal of Green Pharmacy 3(3): 220.
72
Regenerative potential of pancreata in alloxan induced diabetic mice by 4-Hydroxyisoleucine, comparision with pioglitazone
2009
International Journal of Integrative Biology 5(3): 136.
73
Anti-hyperglycaemic activity of IND 01 and its interaction with glyburide and pioglitazone in alloxan induced diabetic mice
2009
Int J Diabetes & Metabolism 17: 21-26.
74
Study of galactomannan on androgenic and anabolic activity in male rats
2008
Pharmacologyonline 2: 56-65.
75
Study of Andropic? on androgenic and anabolic activity in male rats
2007
Pharmacologyonline 3: 1-8.
76
Study of Andropic® on androgenic and anabolic activity in male rats
2007
Pharmacologyonline*, 3: 1-8
77
Effect of trigonelline: an active compound from Trigonella foenum graecum linn. in alloxan induced diabetes in mice
2006
Journal of Cell and Tissue Research 6(1): 585-590.
78
Hypoglycemic activity of combination of active ingredients from Trigonella foenum graecum in alloxan induced diabetic mice.
2006
Pharmacologyonline 1: 65-82.
79
Combinative therapeutic approach for better blood sugar level control in alloxan diabetic mice
2006
International Journal of Diabetes and Metabolism 14: 104-105.
No results found